Synthesis and characterization of some new (1,3-Oxazepine) derivative from 6-methyl 2-thiouracil and study their biological activity

This research includes synthesis of new heterocyclic containing (1,3-oxazepine) derivatives 6- methyl 2-thiouracil. The preparation process started by the reaction 2-thiouracil with ethyl chloroacete to give 2-((4-hydroxy-6-methylpyrimidin-2-yl) thio) acetate (1). Compound (1) reacted hydrazine hydrate 2-((4-hydroxy-6-methylpyrimidin-2-yl)thio) aceto hydrazide (2). That various substituted benzaldehydes in presence glacial acetic acid as catalyst absolute ethanol obtain Schiff bases (3-11). 1,3-oxazepine [12-38] were obtained from treatment each (3-11) (phthalic anhydride ,maleic and succinic anhydride) respectively. Newly synthesized compounds identified via spectral methods; their [FT-IR some them 1H-NMR, 13C-NMR] measurements its physical properties. Furthermore screened for antimicrobial activity against four strains bacteria –ve (Escherichia coli klibsialla) +ve (Bacillus Staphylococcus aureus). Most tested show significant antibacterial activity.